klionwords.blogg.se

Many EvoDevo researchers wished to understand how evolutionary radiation gave rise to the impressive array of biodiversity present in a group of animals called the bilaterians. * Correspondence to: of Biological Sciences, Lehigh University, Bethlehem, PA, USAĢSars Centre for Marine Molecular Biology, University of Bergen, Bergen, NorwayģInstitute for Research on Cancer and Aging (IRCAN), CNRS UMR 7284, INSERM U1081, Université de Nice-Sophia-Antipolis, Nice, FranceĬonflict of interest: The authors have declared no conflicts of interest for this article. WIREs Developmental Biology published by Wiley Periodicals, Inc.

We provide a catalogue of current resources and techniques available to facilitate investigators interested in incorporating Nematostella into their research. Lastly, the sum of research to date in Nematostella has generated a variety of tools that aided the rise of Nematostella to a viable model system. This review intends to highlight key EvoDevo insights from Nematostella that guide our understanding about the evolution of axial patterning mechanisms, mesoderm, and nervous systems in bilaterians, as well as to discuss briefly the potential of Nematostella as a model to better understand the relationship between development and regeneration. However, Nematostella is now going beyond its intended utility with potential as a model to better understand other areas such as regenerative biology, EcoDevo, or stress response. Studies in Nematostella have accomplished this goal and informed our understanding of the evolution of key bilaterian features. Nematostella is a cnidarian (corals, jellyfish, hydras, sea anemones, etc.) animal that was originally targeted by EvoDevo researchers looking to identify a cnidarian animal to which the development of bilaterians (insects, worms, echinoderms, vertebrates, mollusks, etc.) could be compared. This review highlights the rise of one such novel model system, the starlet sea anemone Nematostella vectensis. It is now possible to identify an animal(s) with the unique biology most relevant to a particular question and rapidly generate tools to functionally dissect that biology. Reverse genetics and next-generation sequencing unlocked a new era in biology.

Layden,1* Fabian Rentzsch2 and Eric Rottinger3 The rise of the starlet sea anemone Nematostella vectensis as a model system to investigate development and regeneration